ENTCHEVA LAB NEWS
May 10, 2016
Our Nature Communications paper on high-throughput all-optical electrophysiology comes out and draws attention. The article on Science Daily can be found here.
May 1, 2016
A review/perspective on all-optical electrophysiology comes in the Journal of Physiology, using images from our Nature Photonics paper with Gil Bub on the cover.
April, 4 2016
Dr. Entcheva is inducted as a Fellow of the American Institute for Medical and Biological Engineering (AIMBE) for “pioneering work in cardiac optogenetics & spearheading the development and biophysical characterization of new bioengineering tools towards all-optical electrophysiology
Our lab relocated to The George Washington University into a brand new space in the Science and Engineering Hall.
Collaborative work between my lab and Dr. Gil Bub’s lab at Oxford appeared today in Nature Photonics.
Unlike any application of optogenetics to date (neural or cardiac), beyond triggering or suppressing electrical activity, we demonstrate the first fine “excitation wave steering” using computer-generated dynamic light patterns (movies), while simultaneously tracking the waves with a novel high-resolution interferometric dye-free imaging.
It literally involves twisting cardiac spiral waves around by light – a bit of a science fiction. 🙂
The paper can be found here.
- Phys.org: Researchers learn how to steer the heart with light
- Science Daily: Researchers learn how to steer the heart with light
- Official Stony Brook University Press Release: Researchers learn how to steer the heart with light
- Official Oxford University Press Release: Researchers learn how to steer the heart with light
Press/media coverage of our recent work on cardiac optogenetics – some shown below:
Science Daily: Researchers Aim to Use Light Not Electric Jolts To Restore Healthy Heartbeats
BioOptics World: Optogenetics Could Correct Life-threatening Arrhythmias
Scientific Computing: Using Light Not Jolts To Restore Healthy Heartbeats
Congratulations to Dr. Zhiheng Jia, PhD for completing his PhD! He has been invaluable to the success of the lab and in our first steps into cardiac optogenetics – he will be missed. Jia joins Motorola as an Optical Engineer.
Also graduating this May is Dr. Ujas Shah, MD, a veteran lab member since his first stint with us in 2004 as a high school student – time to leave the Stony Brook nest. He will be starting his residency at Montefiore in NYC.
Finally, congratulations to Cookie Yu, BS, who was chosen to carry the BME banner as an outstanding undergraduate! Cookie will be staying in our lab as a PhD student.
Some Awards for old and new lab members:
Congratulations to Dr. Christina Ambrosi, PhD, a Postdoctoral Fellows, whose paper from prior work with Dr. Igor Efimov was selected as one of top 4 for 2011 in the Heart Rhythm jJournal Christina was invited to give a talk at the Heart Rhythm Society meeting in Boston this month.
Congratulations to John Williams, who will continue working on our computational optogenetics project this summer with an URECA award. Joining him will be Xuxin Chen pursuing MD with scholarly concentration. We are expecting our newest member Mathew Epstein, BME from Binghamton, winner of one of the NYSTEM awards for undergraduates.
Dr. Entcheva and her team have been awarded a five-year $2.43M grant from the National Institutes of Health “Cardiac Optogenetics: A Cell Delivery Approach” – the first grant by NIH to specifically expand the new field of optogenetics to the heart. Dr. Entcheva’s team has pioneered the application of light-sensitive ion channels to mammalian cardiac tissue and the integration of optogenetics with high-speed, high-resolution optical imaging of excitation. This grant, a collaborative work with Drs. Ira Cohen and Peter Brink, draws on expertise in optical mapping, mathematical modeling, and genetic modification of stem cells for use in cardiac electrophysiology. It aims to develop a quantitative framework for cardiac optogenetics in silico, in vitro and in vivo and to allow imaging and actuation of heart tissue by light with unprecedented spatiotemporal resolution for the better understanding, prevention and termination of life-threatening cardiac arrhythmias.
Press/media coverage of our recent work on cardiac optogenetics – some shown below:
- American Heart Association
- MIT’s Technology Review
- Science Daily
- Stony Brook University News
Wedding bells for current and former lab members this August!
- Former lab member Rupinder gets married to lovely Ayesa – an Indian wedding in New York!
- Marcel (our German-in-Japan visiting scientist) ties the knot with lovely Marina – a Japanese wedding!
- Kwan (new lab member) gets married – a wedding in Taiwan!
Good luck to all!!!
New grants: Ujas (now medical student) was awarded the highly competitive Glorney-Raisbeck fellowship in cardiovascular disease from the New York Academy of Medicine to perform research in the lab.
Jackie won a summer URECA fellowship, and Sandy will spend the summer at NIH supported by a bioengineering fellowship.
Congratulations to multiple graduates affiliated with the lab!
Harold obtains his MD; Steve, Aashay, Budassi, Hala, and Syed get their B.S. in Biomedical Engineering and Mitch graduates from high school!
Mitch deservingly becomes a semi-finalist in the Intel Science Talent competition 2008-2009 for his research project in the lab!
Our lab congratulates multiple graduates!
CY and Pei get their PhD degrees in BME and Computer Science, respectively; Ujas, Ravi and Sal get their BME Bachelors degrees!
Former lab member Lihong gives birth to sweet baby Cyndi!
Our lab is part of a newly NIH-funded grant to establish a Systems Biology Center in New York State (SBCNY). This is a collaborative large-scale effort involving Mount Sinai School of Medicine (MSSM), Columbia University College of Physicians, Stony Brook University, Courant Institute for Mathematical Sciences at NYU, City College CUNY and IBM TJ Watson Research Lab.
After an impressive PhD work in the lab, our superstar – Harold Bien – obtained his PhD degree and got back to finish up medical school (for his MD/PhD). He was recognized as one of the top five PhD students this year to receive the President’s Award for Distinguished Doctoral Students. Well deserved, and science needs you, Harold!
Ujas Shah becomes the second Goldwater scholar from our lab!
This competitive scholarship program recognizes the best undergraduates in science and engineering nationwide.
Our review article on optical mapping, which appeared in Progress in Biophysics and Molecular Biology this year, was featured in Biophotonics International, p.61, under a heading “Toward Ideal Imaging Equipment”.
Rupinder Singh becomes the second private pilot from the lab!
Congratulations to Rupinder Singh, selected as the outstanding BME senior for the 2006 graduating class! And off he goes to Cornell! Good luck!
Ujas Shah got the academic year (2006/07) Howard Hughes award (despite the fact that he is just a freshman)!
LAB UNDERGRADS SWEEP MORE AWARDS: Lenny and Rupinder received recognition awards for excellence in research. A hat-trick: Lenny, Ujas, and Ravi got the URECA award to conduct research in the Summer of 2006.
Lenny Varghese is awarded a fellowship from the Barry M. Goldwater Scholarship and Excellence in Education Program.
Emilia Entcheva has been awarded two grants from the National Science Foundation – an experimental grant on bioelectricity and cell signaling and a computational grant on applying hybrid automata to biological problems in collaboration with the Computer Science Department.
Congratulations to Melissa Farrell and Hui-Jing Yu, graduating with B.S. in BME! For her academic and research excellence, Hui-Jing has been selected as the outstanding BME senior for the 2005 graduating class
Lenny Varghese has been selected Howard Hughes Scholar for Summer 2005
Our “acoustic micromachining” article in Lab-on-a-Chip has been selected as a “hot article” by the Royal Society of Chemistry (RSC), and featured here: “Microchips killed the radio star”
Harold Bien becomes officially a private pilot!
Harold Bien is awarded National Institute of Environmental Health Sciences (NIEHS) Fellowship entitled “Myocardial Response to Particulate Matter Air Pollution”
Lihong Yin is awarded the Master’s Degree in Biomedical Engineering (Thesis: “Intracellular Calcium Dynamics in Engineered Cardiomyocyte Networks”)
- Vikram Dasari admitted to Albert Einstein Medical College for graduate school.
- Melissa Farrell wins Undergraduate Recognition Award.
Emilia Entcheva was awarded a 4 year grant by the American Heart Association to study the hypertropy arrhythmias connection in an engineered model of heart tissue.
Emilia Entcheva was awarded a 3 year Research Grant by the Whitaker Foundation: “Electromechanical performance of engineered cardiac syncytia on complex surfaces”
Lihong Yin was the only Stony Brook student to receive a Sigma Xi Research Grant
- Hui Jing Yu received a summer fellowship through IBRP (Interdisciplinary Biomedical Research Program)
Cover illustration in April 2003 issue of Journal of Cell Science, accompanying D. Ingber’s “Commentary on Tensegrity”; Entcheva E, Bien H, and Yin L. “Mechanical and spatial determinants of cytoskeletal geodesic dome formation in cardiac fibroblasts” (submitted manuscript)
Melissa Farrell was awarded Howard Hughes Medical Institute Summer fellowship
Harold Bien won 1st Place in the Annual IEEE Engineering in Medicine & Biology Conference Student Paper Competition at the Second Joined BMES and IEEE EMBS Meeting in Houston, TX
Lihong Yin and Harold Bien were elected into Sigma Xi for excellence in research