Research Focus

The Cardiac Optogenetics and Optical Imaging Lab is part of the Biomedical Engineering Department at George Washington University. We use state-of-the-art engineering approaches and methods to gain insights about the electrical and mechanical function of cardiac cells and heart tissue. New tools for optical actuation and sensing/imaging/control help us elucidate the mechanisms of normal and abnormal excitation in the heart, including the origin of life-threatening arrhythmias. Our work yields new experimental models for physiomics type of studies, drug and gene therapy testing 3D cellular platforms, an experimental setting for validation of computer models of excitable tissue. This research is multidisciplinary and involves a spectrum of experimental molecular and cell biology procedures, along with the application of design concepts from electrical, optical, mechanical and chemical engineering to create the enabling technology for our studies. Image processing algorithms and computer modeling are essential complementary tools, developed and applied by our team.

Key Research Areas

Cardiac Optogenetics

 

Ultra-High Resolution Optical mapping of Excitation and Contraction

 

Mechanisms of Cardiac Arrhythmias

 

Computational Modeling in Electrophysiology

 

Cardiac Cell and Tissue Engineering

 

Signal and Image Processing